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1 When various Avengers and X-Men were inverted into villains and several villains inverted into heroism due to a miscast spell by the Scarlet Witch and Doctor Doom, Rogers not only coordinated the efforts of Spider-Man and the inverted villains, now called the "Astonishing Avengers", but also donned his old armor to battle the inverted Falcon, until the heroes and villains could be returned to normal with the aid of the White Skull (the inverted Red Skull).

2 In the Marvel Mangaverse reality, the original Captain America is decapitated and killed by Doctor Doom, but Carol Danvers assumes the identity.

3 In the 2010s, it is unknown if he is dead or in hiding after Doctor Doom took over the planet.

4 When Magneto arrived with his supervillain allies, Doctor Doom and Scarlet Witch attempted to cast the inversion spell again and Red Onslaught was knocked unconscious and reverted to his Red Skull form.

5 The team is also well known for its recurring encounters with characters such as the villainous monarch Doctor Doom, the planet-devouring Galactus, the Kree Empire's ruthless and tyrannical enforcer Ronan the Accuser, Annihilus, ruler of the Negative Zone, the sea-dwelling prince Namor, the spacefaring Silver Surfer, and the Skrull warrior Kl'rt. The Fantastic Four have been adapted into other media, including four animated series and four live-action films.

6 Issue #5 (July 1962) introduced the team's most frequent nemesis, Doctor Doom.

7 The following year's annual revealed the origin story of Doctor Doom.

8 Marv Wolfman and Keith Pollard crafted a multi-issue storyline involving the son of Doctor Doom which culminated in issue #200 (Nov.

9 Ventura departed after being further mutated by Doctor Doom.

10 the return of Reed's time-traveling father, Nathaniel, who is revealed to be the father of time-travelling villain Kang the Conqueror and Reed's apparent death at the hands of a seemingly mortally wounded Doctor Doom.

11 The Baxter Building was replaced by Four Freedoms Plaza at the same location after its destruction at the hands of Kristoff Vernard, adopted son of the team's seminal foe Doctor Doom.

12 Some of these characters include, but are not limited to: Namor the Sub-Mariner (previously an antagonist), Alicia Masters, Lyja the Lazerfist, H.E.R.B.I.E., Kristoff Vernard (Doctor Doom's former protégé), Wyatt Wingfoot, Sue and Johnny's father Franklin Storm, the receptionist android Roberta, governess Agatha Harkness, and Reed and Sue's children Franklin Richards and Valeria Richards.

13 Some of the team's oldest and most frequent enmities have involved such foes as the Mole Man, the Skrulls, Namor the Sub-Mariner, Doctor Doom, the Puppet Master, Kang the Conqueror/Rama-Tut/Immortus, Blastaar, the Frightful Four, Annihilus, Galactus, and Klaw.

14 Also in the cast were Bob Maxwell as Reed Richards, Cynthia Adler as Sue Storm, Jim Pappas as Ben Grimm and Jerry Terheyden as Doctor Doom.

15 The most expansive appearances are in the episode "The Private War of Doctor Doom", in which the Avengers team up with the Fantastic Four to battle the titular supervillain, and in the final episode of season two, in which the groups team up to battle Galactus.

16 A film adaptation of the characters, The Fantastic Four, was completed in 1994 by producer Roger Corman and starred Alex Hyde-White as Reed Richards/Mr. Fantastic, Rebecca Staab as Sue Storm-Richards/Invisible Woman, Jay Underwood as Johnny Storm/Human Torch, Michael Bailey Smith as Ben Grimm and Carl Ciarfalio as The Thing and Joseph Culp as Victor von Doom/Doctor Doom.

17 The film stars Miles Teller as Reed Richards, Kate Mara as Sue Storm, Michael B. Jordan as Johnny Storm, Jamie Bell as Ben Grimm and Toby Kebbell as Doctor Doom.

18 All of the Fantastic Four appear as playable characters in the game Marvel: Ultimate Alliance with Doctor Doom being the main enemy.

19 During the Secret Wars, Galactus attempts to consume Battleworld in order to force the Beyonder to remove his hunger, but his plan is foiled by Doctor Doom.

20 Returning to Earth, Galactus has a confrontation with Doctor Doom and the Fantastic Four, with Doom revealing his plans to harness Galactus's power as an energy source.