He was deposed in 623 BCE by an Assyrian general (turtanu) named Sin-shumu-lishir (623–622 BCE), who was also declared king of Babylon.
The deuterocanonical book of Judith (Yehudit or Yehudis in Hebrew), which is not part of the Tanakh, records that Holofernes, an Assyrian general, had surrounded the village of Bethulia as part of his campaign to conquer Judea.
House to house fighting continued in Nineveh, and an Assyrian general and member of the royal household, took the throne as Ashur-uballit II (612–605 BC).
Realizing the threat this posed, Sinsharishkun led a massive counterattack himself which saw the successful recapture of Uruk in 623 BC. Sinsharishkun might have ultimately been victorious had it not been for another revolt, led by an Assyrian general in the empire's western provinces in 622 BC. This general, whose name remains unknown, took advantage of the absence of Sinsharishkun and the Assyrian army to march on Nineveh, met a hastily organized army which surrendered without fighting and successfully seized the Assyrian throne.
It tells of a Jewish widow, Judith, who uses her beauty and charm to destroy an Assyrian general and save Israel from oppression.
Holofernes was an Assyrian general and king, often drunk and constantly monstrous.