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1 Glucose requirements above 10 mg/kg/minute in infants, or 6 mg/kg/minute in children and adults are strong evidence for hyperinsulinism.

2 Some forms of congenital hyperinsulinism respond to diazoxide or octreotide.

3 Surgical removal of the overactive part of the pancreas is curative with minimal risk when hyperinsulinism is focal or due to a benign insulin-producing tumor of the pancreas.

4 When congenital hyperinsulinism is diffuse and refractory to medications, near-total pancreatectomy may be the treatment of last resort, but in this condition is less consistently effective and fraught with more complications.

5 in hypoglycemia, due to causes other than hyperinsulinism;

6 The first case of hyperinsulinism due to a tumor of this type was reported in 1927.