Glucose requirements above 10 mg/kg/minute in infants, or 6 mg/kg/minute in children and adults are strong evidence for hyperinsulinism.
Some forms of congenital hyperinsulinism respond to diazoxide or octreotide.
Surgical removal of the overactive part of the pancreas is curative with minimal risk when hyperinsulinism is focal or due to a benign insulin-producing tumor of the pancreas.
When congenital hyperinsulinism is diffuse and refractory to medications, near-total pancreatectomy may be the treatment of last resort, but in this condition is less consistently effective and fraught with more complications.
in hypoglycemia, due to causes other than hyperinsulinism;
The first case of hyperinsulinism due to a tumor of this type was reported in 1927.